Method of Fractionating Peptides and Other Compounds
Project Leaders: Daniel Dyer, Gary Kinsel
Department: Chemistry and Biochemistry
Intellectual Property Status:
Patent pending.
Executive Summary:
Matrix assisted laser desorption ionization mass spectrometry (MALDI MS) is a powerful mass spectrometry technique that allows for the characterization of a variety of biomolecules. MALDI MS however suffers considerable loss of performance in the direct characterization of complex peptide/protein mixtures. In response to this limitation, isolation of the peptide/protein of interest is typically performed prior to MALDI MS. The invention provides a method of isolation that is faster, less labor intensive and more efficient than existing methods.
Brief Description of Technology:
The invention relates to a method of fractionating a mixed sample to obtain a target fraction. More particularly, the invention relates to a method of fractionating a target fraction with a polymer brush that selectively sorbs the target fraction on contact, and contracts in response to an external stimulus to the target fraction.
Contact:
Jeff Myers, Senior Technology Transfer Specialist, (618) 453-4543, fax: (618) 453-8038